Fuel Types
Different fuel types such as methane, hydrogen, RP-1,
liquid oxygen (obviously), and other various fuels. The player would then have to design their rockets with appropriate fuel types depending on the engines they use.
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Jangus Wright commented
maybe a version where you can choose maybe just Kerosene/LOX or Liquid Hydrogen/LOX, solid fuel mixtures or hyperbolics (for upper stages) and Hydrogen Peroxide Monoprop for each of your engines. maybe RP-1 is the cheaper but less efficient option, and hydrogen is much more efficient but more expensive. the iSP of each engine can change based on your fuel (and maybe oxidiser) choices.
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Anonymous commented
Also factories to produce it on the earth